Can I still apply for restoration if I became inadmissible for a new reason after my original permit was issued?

Generally, no, not without resolving the new issue first. Restoration eligibility is assessed as of the time of the restoration application itself, not just against the requirements that applied when your original permit was issued. If a new ground of inadmissibility has arisen since then — for example, a new criminal charge or conviction, a misrepresentation finding, or a new health or security concern — that issue generally needs to be resolved, or specifically overcome, before restoration can be granted.

This catches people off guard because they assume restoration simply reactivates their original approved status, when in fact IRCC is assessing the whole picture as it currently stands, including anything that has changed since the original permit was granted. A restoration application filed without addressing a new inadmissibility concern is likely to be refused on that basis, separate from any question about the original permit's expiry.

Anyone facing this situation should get the specific new inadmissibility issue assessed clearly before applying for restoration, since submitting the application without addressing it can also make the underlying problem harder to resolve afterward.